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Hypertrophic Subaortic stenosis

768,74 €

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Lieferzeit 14-21 Werktage

  • MP2036
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Clinical History A thin 42-year-old American tourist was found dead in his hotel bedroom. A... mehr
Produktinformationen "Hypertrophic Subaortic stenosis"
Clinical History
A thin 42-year-old American tourist was found dead in his hotel bedroom. A coroner’s autopsy was performed.

Pathology
This is a longitudinal section through the heart displaying the left and right ventricles and interventricular septum. The outstanding abnormality is a grossly thickened interventricular septum and left ventricular hypertrophy. The aortic cusps that are visible appear unremarkable, as does the mitral valve. The ventricular septum is so large that it encroaches on the lumen of the left ventricle.

Diagnosis
Idiopathic hypertrophic subaortic stenosis, also known as hypertrophic cardiomyopathy.

Further Information
Subaortic stenosis is considered to be acquired rather than congenital and is suggested to result from an underlying defect in the architecture of the left ventricular outflow tract (LVOT). The defect may be such that the resulting turbulent blood flow leads to progressive thickening and fibrosis of the LVOT and the aortic valve. Progression of the disease will often lead to a hypertrophic cardiomyopathy secondary to the increased aortic pressure needed to be overcome by the left ventricle. Mild or moderate stenosis is often asymptomatic. As disease progresses and the stenosis becomes severe, symptoms such as exertional dyspnoea and syncope may become apparent. Investigation and subsequent diagnosis are often prompted by the presence of an ejection systolic murmur on physical examination. Echocardiography is used to confirm diagnosis.
These days, definitive treatment of subaortic stenosis consists of surgical correction of the obstruction.
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